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Multiple Sclerosis Research Group

Faculty

Jorge R. Oksenberg, Ph.D.

Professor in the Department of Neurology,
University of California at San Francisco (UCSF)

Jorge R. Oksenberg

E-mail:

Dr. Oksenberg is the G.A. Zimmermann Endowed Chair in Neurology. He received his Ph.D. in Immunology from the Hebrew University of Jerusalem, Israel, and joined the UCSF faculty in 1993 following post-doctoral training at Stanford University. Since 1979 his research has focused in the areas of human immunogenetics and the control of the immune response. He authored numerous publication and scholarly reviews in the field. Dr. Oksenberg is a leading investigator in the International Multiple Sclerosis Genetics Consortium. Since 2005, Dr. Oksenberg serves as Associate Editor for the Annals of Neurology.

Stephen L. Hauser, M.D.

Professor and Chair of the Department of Neurology

Stephen L. Hauser M.D.

E-mail:

Dr. Hauser is a graduate of Massachusetts Institute of Technology and the Harvard Medical School. He trained in internal medicine at the New York Hospital/Cornell Medical Center and in neurology at the Massachusetts General Hospital/Harvard Medical School. Following postdoctoral fellowships in immunology at Harvard Medical School and the Pasteur Institute in Paris, France, he joined the faculty at Harvard and established an independent laboratory at the Massachusetts General Hospital. Since 1992, he has served as chairman and Robert A. Fishman Distinguished Professor of the Department of Neurology at UCSF. Dr. Hauser’s research has focused on MS immunology and genetics. He was responsible for one of the first clinical trials of immunosuppression on the course of progressive MS. His early work identified the CD4 T-cell as important in MS and also in experimental models of demyelination. His laboratory also played a central role in elucidating the role of pathogenic autoantibodies in demyelination, culminating in a clinical trial showing the benefit of Rituximab, a monoclonal antibody that selectively targets and depletes CD20+ B lymphocytes. He is a fellow of the American Academy of Arts and Sciences and the American Association of Physicians, a member of the Institute of Medicine and serves as an editor of the medical textbook Harrison’s Principles of Internal Medicine and Chief Editor of the Annals of Neurology.

Sergio Baranzini, Ph.D.

Associate Professor at the Department of Neurology, UCSF

Sergio Baranzini Ph.D.

Dr. Baranzini has over 15 years of experience working in human genetics projects. A graduate from the University of Buenos Aires, Argentina, his is initial research focused on genotype-phenotype correlations in Mendelian disorders. Since 1997 Dr. Baranzini has been involved in gene expression analysis and his current research focuses on characterizing the molecular mechanisms of homeostasis and disease in the context of human and experimental demyelination. To this end, he uses a combination of “wet lab” methods including DNA microarrays, proteomics, and laser capture microdissection, in combination with “dry lab” analytical approaches encompassing bioinformatics, complexity theory, and mathematical modeling. website: baranzinilab.ucsf.edu

Bruce C. Cree, M.D., Ph.D.

Assistant Professor of Neurology,
University of California San Francisco Multiple Sclerosis Center

Bruce C. Cree M.D. Ph.D.

Dr. Cree is board certified in neurology. After graduating from Brown University, Providence, Rhode Island, Dr. Cree earned his medical degree and his PhD from the University of California San Francisco. He completed his residency in Neurology at New York Presbyterian Hospital (Columbia University), New York City, where he was chief resident. He returned to UCSF where he undertook postdoctoral subspecialty training in multiple sclerosis as a Sylvia Lawry fellow. Additionally, he received a Master’s degree in Clinical Research. Dr. Cree has served as an investigator on numerous clinical studies in multiple sclerosis. Much of his research has focused on multiple sclerosis epidemiology and outcomes.

Pierre-Antoine Gourraud, Ph.D., MPH

Assistant Professor at the Department of Neurology, UCSF

Pierre-Antoine Gourraud Ph.D.

Pierre-Antoine Gourraud is a former student of the Ecole Normale Supérieure de Lyon in France. After receiving an M.P.H. from University Paris XIII in 2002, he got his Ph.D. in Immunogenetic Epidemiology and Public Health from Toulouse University in 2005. He relocated to the United States to do his postdoctoral research in Neuroimmunogenetics of multiple sclerosis at UCSF in 2009 and joined the UCSF faculty in 2011. Dr Gourraud has established numerous research collaborations with investigators from all over the world: He develops bioinformatics resources at the National Center for Biotechnology Information (Immunogenetics markers: HLA, KIR, Microsatellites). At UCSF, he performs new generation of MS genetic association studies using massive sequencing technologies in various genetic ancestry backgrounds and continues developing software dedicated to translational digital medicine. His recent efforts have focused on the “MS Bioscreen”, a tablet-based navigation-system that integrates multiple dimensions of patient information including clinical evolution, therapeutic treatments, brain imaging, genomics and biomarker data.