Jean-Christophe Corvol, M.D., Ph.D.

Postdoctoral Fellow

Department of Neurology
University of California San Francisco
(415) 476-3136

Education and Training

• 1995 National Exam for Medical Residency, France, rank #1
• 2001 M.D., Neurology, University Paris V, Paris, France
• 2005 Ph.D., University Paris VI, Paris, France

Awards and Honors

• 2006 “Prix Jeune Chercheur”, Bettencourt-Schueller Fondation, France

Research experience

• 2001-2005 Ph.D., Signal Transduction and Neuronal Plasticity Laboratory, Fer à Moulin Institute, Paris, France. Subject: dopamine D1 receptor signaling in Parkinson’s disease and mice models of addiction.
• 2003-2006 Chief Residency, Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France. Clinical research: PI in clinical trials in Pharmacology of Parkinson’s disease.

Research interest

Keywords:
Multiple Sclerosis, gene expression, transcriptomics

The overall goal of my project is to identify molecular biomarkers predictors of magnetic resonance imaging (MRI) activity in multiple sclerosis. In a Clinical Isolated Syndrome (CIS) longitudinal cohort, large-scale gene expression analysis in peripheral blood lymphocytes is combined with clinical data and quantitative MRI variables such as lesion volume, brain atrophy, metabolite concentration, etc. Using training machine learning algorithms with expression and MRI data, transcriptional profiling of samples are used to create predictive models of MRI progression. Temporal gene expression changes will be correlated to MRI variables at different time points to find promising candidate genes involved in lesion formation.

Other

Recent Publications
Corvol JC, Valjent E, Toutant M, Enslen H, Irinopoulou T, Lev S, Herve D, Girault JA. (2005) Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. J Biol Chem. 280:660-8